Comparison of postoperative deglutition disorder in patients with laryngeal carcinoma after different types of supracricoid partial laryngectomy / 中华肿瘤杂志

<p><b>OBJECTIVE</b>To Evaluate the incidence rates and extents of deglutition disorder in patients with laryngeal carcinoma after different types of supracricoid partial laryngectomy.</p><p><b>METHODS</b>Retrospective analysis of postoperative deglutition disorder in patients with laryngeal carcinoma after different types of supracricoid partial laryngectomy treated in our department from 2005 to 2009. The extents of postoperative deglutition disorder were evaluated using a homemade quantitative score table at 5-20 days postoperation.</p><p><b>RESULTS</b>The score of deglutition disorder was 2.71 ± 0.31 in the supracricoid partial laryngectomy-cricohyoidoepiglottopexy (SCPL-CHEP) operation group and 3.43 ± 0.64 in the supracricoid partial laryngectomy-cricohyoidopexy (SCPL-CHP) group, respectively. The deference was statistically significant between the two groups (P < 0.001). The coefficient between age and score of postoperative deglutition disorder was assessed by Pearson correlation analysis. The coefficient of correlation was 0.947 (P < 0.0001) in the SCPL-CHEP group and 0.907 (P < 0.0001) in the SCPL-CHP group. The incidence rate of deglutition disorder was 1/37 in the SCPL-CHEP group and 7/30 in the SCPL-CHP group, evaluated at 8 weeks postoperation (P = 0.012). The deference between the two groups was significant.</p><p><b>CONCLUSIONS</b>The type of operation procedure is an important factor affecting the occurrence of postoperative deglutition disorder in the patients after supracricoid partial laryngectomy, more serious in the SCPL-CHP group. The severity of postoperative deglutition disorder is more serious along with the increase of patient's age. For the elderly (> 70 years of age) patients with laryngeal carcinoma, the choice of surgical procedure should be more cautious, especially with the SCPL-CHP operation.</p>

Expression of c-fos and NR2A in auditory cortex of rats experienced tinnitus / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To investigate the plasticity and the role of plasticity in the auditory cortex of rats which experienced tinnitus by screening the plasticity markers immediately early gene c-fos and the NMDA receptor's subtype NR2A.</p><p><b>METHODS</b>Thirty white Wistar rats were randomly distributed into 3 groups: sodium salicylate group (n = 12), physiological saline group (n = 12) and normal control group (n = 6). Tinnitus were induced by salicylate administration and tested by behavioral conditioning studies, and then immunohistochemical staining was used to observe the expression of c-fos and NR2A in the auditory cortex of each group.</p><p><b>RESULTS</b>Behavioral evidence indicated that all of the twelve rats in the sodium salicylate group perceived tinnitus. Fos-positive neurons were observed in all rats, while they appeared as typical dark dots, corresponding to a labeling restricted to their nucleus. NR2A protein was mainly expressed in the cytoplast and membrane of the cortical pyramidal cells. The expression of c-fos and NR2A immunoreactive neurons in auditory cortexes of the sodium salicylate group was significantly higher than that of other two control groups.</p><p><b>CONCLUSIONS</b>The higher expression of c-fos and NR2A indicate that the neurotransmitters and receptors should be involved in the tinnitus, as well as suggest that neuronal plasticity occurs in the auditory cortex of rats experienced tinnitus, which may be played an important role in the mechanism of tinnitus.</p>